Carbonic anhydrase I and II autoantibodies in Behcet's disease


Mentese A. , Alver A., Demir S., Sumer A., Yaman S O., Karkucak M., ...More

ACTA REUMATOLOGICA PORTUGUESA, vol.42, no.1, pp.26-31, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 1
  • Publication Date: 2017
  • Title of Journal : ACTA REUMATOLOGICA PORTUGUESA
  • Page Numbers: pp.26-31
  • Keywords: Autoantibody, Behcet's disease, Carbonic anhydrase, OXIDATIVE STRESS, ANTIBODIES, AUTOIMMUNITY

Abstract

Background: Behcet's disease ( BD) is a vasculitis, seen more frequently around the Mediterranean and the Far East, and evinces with oral and genital ulcerations, skin lesions and uveitis. Carbonic anhydrase ( CA) is a metalloenzyme which is widely distributed in the living world, and it is essential for the regulation of acid-base balance. Anti-CA antibodies have been reported in many disorders, such as systemic lupus erythematosus, Sjogren's syndrome, rheumatoid arthritis, endometriosis, idiopathic chronic pancreatitis, type 1 diabetes and Graves' disease. The goal of this study was to investigate CA I and II autoantibodies in BD.