Antibacterial Activity and Physical Properties of Glass-ionomer Cements Containing Antibiotics

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OPERATIVE DENTISTRY, vol.34, no.1, pp.18-23, 2009 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 1
  • Publication Date: 2009
  • Doi Number: 10.2341/08-30
  • Title of Journal : OPERATIVE DENTISTRY
  • Page Numbers: pp.18-23


This study evaluated the antibacterial effects, physical properties and bonding strengths of conventional glass-ionomer cements (GICs) con- taining antibiotics and determined the optimal concentration of antibiotics addition for use with the ART approach. Fuji IX GIC was used as a control. Three antibiotic mixtures, ciprofloxacin, metronidazole and minocycline, were added to powdered GIC (Fuji IX) to obtain concentration ratios of 1.5, 3.0 and 4.5% w/w. The antibacterial activity of each GIC was evaluated against Streptococcus mutans or Lactobacillus casei using agar-diffusion methods. The release of antibiotics was analyzed by high-performance liquid chromatography (HPLC). The compressive strength and bonding strength to dentin were measured and compared with those of control samples. The results were analyzed using the Mann-Whitney test and Wilcoxon test. All tested groups showed a significantly greater inhibition with growth of the selected bacteria in comparison to the control groups (p<0.01). However, the 3% and 4.5% concentration ratios of antibiotics had significantly lower compressive strength and lower bond strength to dentin than the control group (p=0.003). The GIC-containing anti-biotics were effective in inhibiting S Mutans and L Casei. The addition of a 1.5% antibiotic mixture was optimal to giving appropriate physical and bonding properties.