Determinants of Leaky Gut and Gut Microbiota Differences in Children With Autism Spectrum Disorder and Their Siblings.

Yitik Tonkaz G., Esin I. S., Turan B., Uslu H., Dursun O. B.

Journal of autism and developmental disorders, vol.53, no.7, pp.2703-2716, 2023 (SSCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 53 Issue: 7
  • Publication Date: 2023
  • Doi Number: 10.1007/s10803-022-05540-z
  • Journal Name: Journal of autism and developmental disorders
  • Journal Indexes: Social Sciences Citation Index (SSCI), Scopus, Academic Search Premier, ASSIA, PASCAL, BIOSIS, Child Development & Adolescent Studies, CINAHL, EBSCO Education Source, Education Abstracts, Educational research abstracts (ERA), EMBASE, ERIC (Education Resources Information Center), Linguistics & Language Behavior Abstracts, MEDLINE, Psycinfo, Public Affairs Index
  • Page Numbers: pp.2703-2716
  • Keywords: Autism, microbiota, LBP, s-CD14, Fecal calprotectin, REAL-TIME PCR, CASEIN-FREE DIET, FECAL CALPROTECTIN, GLUTEN-FREE, GASTROINTESTINAL DYSFUNCTION, SOLUBLE CD14, INFLAMMATION, BEHAVIOR, DISEASE, FECES
  • Karadeniz Technical University Affiliated: Yes

Abstract

Leaky gut hypothesis is one of the well-known theory which tries to explain etiology of Autism Spectrum Disorder (ASD). Unfortunately there is still a gap of evidence to investigate the corner points of the hypothesis. The aim of this study was to investigate the determinants of leaky gut in children with ASD, their siblings and healthy controls. Intestinal microbiota was found to be similar between ASD and sibling groups. Biological markers of bacterial translocation showed a significant difference in the sibling group, whereas the marker indicating local inflammation was not different between the groups. The findings from this study did not support the role of Gut microbiota or leaky gut on the etiology of autism.