This study aimed to predict the CNC cutting conditions for the best wood surface quality, energy, and time savings using artificial neural network (ANN) models. In the CNC process, walnut, and ash wood were used as materials, while three different cutting tool diameters (3 mm, 6 mm, and 8 mm), spindle speed (12000 rpm, 15000 rpm, and 18000 rpm), and feed rate (3 m/min, 6 m/min, and 9 m/min) were determined as cutting conditions. After the cutting processes were completed with the CNC machine, energy consumption and processing time were determined for all groups. Surface roughness and wettability tests were performed on the processed wood samples, and their surface qualities were determined. The experimentally obtained data were analysed in ANN, and the models with the best performance were obtained. By using these prediction models, optimum cutting conditions were determined. Using the findings of the study, the optimum cutting condition values can be determined for walnut and ash wood with the smoothest and best wettable surface. Furthermore, in CNC processes using such materials, minimum energy consumption and shorter processing time can be obtained with optimum cutting conditions.