Akademik Veri Yönetim Sistemi
CYSTITIS - UPDATES AND CHALLENGES, Ph.D. Giovanni Palleschi, Editör, IntechOpen, London, ss.1-17, 2023
Cystitis is an inflammatory
condition of the urinary bladder with infectious or noninfectious etiologies.
Chemical-induced cystitis represent a relatively high prevelant kind of
noninfectious cystitis resulting from therapeutic agents or environmental chemicals.
Drug-related cystitis is a type of urotoxicity of drugs, which is commonly
underreported condition leading to impaired quality of patients’ life,
discontinuation of medication and noncompliance. Drug-related cystitis can
occur in several forms ranging from mild urinary symptoms to gross hematuria,
which can be challenging for physicians to treat. Chemotherapeutic drugs, ketamine,
tiaprofenic acid and several drugs have been reported to be associated with
cystitis until now. Cyclophosphamide (CP) is an alkylating agent that leads to hemorrhagic
cystitis with widespread awareness due to its high prevalence in the patients
under treatment intravenously. However, several currently available drugs have
been also reported to induce cystitis, which may be usually ignored.
Drug-related cystitis can cause emergency admissions and prolonged
hospitalization, leading to increased medical costs. Some cases of drug-related
cystitis are clinically managed with established therapeutic interventions
and/or prophylaxis, like CP-induced
hemorrhagic cystitis. On the other hand, standard treatment is currently
unavailable for most cases. This chapter will provide current knowledge
regarding the drug-related cystitis that should be taken into consideration as
a potential adverse effect of drugs by physicians.