Investigation of bla(KPC) Gene by PCR in Carbapenem-Resistant Escherichia coli and Klebsiella pneumoniae Clinical Isolates in a Tertiary Care Hospital in Turkey

Ozyazici G., ÖZKAYA E., Kaya H., KOCATÜRK SEL S., Altinbasak H., Basari F., ...More

MEDITERRANEAN JOURNAL OF INFECTION MICROBES AND ANTIMICROBIALS, vol.8, 2019 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 8
  • Publication Date: 2019
  • Doi Number: 10.4274/mjima.galenos.2019.2019.3
  • Journal Name: MEDITERRANEAN JOURNAL OF INFECTION MICROBES AND ANTIMICROBIALS
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
  • Keywords: Carbapenemase, bla(KPC) gene, molecular epidemiology, urinary tract infection, modified Hodge test, SPECTRUM BETA-LACTAMASE, STRAINS, OUTBREAK, ENTEROBACTERIACEAE, IDENTIFICATION, INFECTIONS, ERTAPENEM, SPREAD, UNIT
  • Karadeniz Technical University Affiliated: Yes

Abstract

Introduction: One of the most common mechanisms in the development of carbapenem resistance is acquiring carbapenemases. A new and different carbapenemase, Klebsiella pneumoniae carbapenemase (KPC), has recently emerged in Turkey. Klebsiella pneumoniae carbapenemases are encoded by the bla(KPC) gene and can be transferred between different species. Reports showing the presence of bla(KPC) gene in isolates from Turkey are limited. The current study aimed to investigate the presence of bla(KPC) gene in carbapenem resistant K. pneumoniae and Escherichia coli isolates in a tertiary care hospital in Turkey.