Synthesis and antitumor activities of some 4,5-dihydro-1H-1,2,4-triazol-5-ones

Ikizler A. A., Ikizler A., Serdar M., YILDIRIM N.

Acta Poloniae Pharmaceutica - Drug Research, vol.54, no.5, pp.363-370, 1997 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 54 Issue: 5
  • Publication Date: 1997
  • Journal Name: Acta Poloniae Pharmaceutica - Drug Research
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.363-370
  • Karadeniz Technical University Affiliated: Yes


Eight new 3-alkyl(aryl)-4-arylidenamino-4,5-dihydro-1H-1,2,4-triazol-5-ones were synthesized and characterised by elemental analysis, 1H NMR, IR and UV spectra. Seven new and 34 recently reported derivatives of 4,5-dihydro-1H-1,2,4-triazol-5-one ring were screened for their antitumor activities.