The impact of migraine on epilepsy: a prospective prognosis study

Velioglu S., Boz C., Ozmenoglu M.

CEPHALALGIA, cilt.25, sa.7, ss.528-535, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 7
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1111/j.1468-2982.2005.00912.x
  • Dergi Adı: CEPHALALGIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.528-535
  • Anahtar Kelimeler: epilepsy, migraine, prognosis, NATIONAL GENERAL-PRACTICE, SEIZURES, REMISSION, COMORBIDITY, PREDICTORS
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

The effect of migraine on the prognosis of epilepsy has not been reported. The aim of this prospective 5-10-year follow-up study was to examine some outcome measures and the cumulative probability of being seizure-free in epilepsy patients with migraine, and to compare their results with those of epilepsy patients without migraine. Fifty-nine patients (40 women; mean age 25 years) were diagnosed with both epilepsy and migraine (EM group). The control group consisted of 56 patients with epilepsy but without migraine (E group). Both groups were recruited and followed up over similar periods. We compared the outcome variables in the EM group with those in the E group. Kaplan-Meier methods were used to assess the seizure-free curves. The EM group had a significantly lower cumulative probability of being seizure-free over 10 years compared with the E group. The other epilepsy outcome measures at follow-up differed significantly between the groups, with the EM group having a longer duration of epilepsy, a lower early treatment response, and a higher incidence of intractable epilepsy and achieving remission with polytherapy, and more seizure control and medication problems for at least the last 2 years of follow-up. Comorbid migraine had a negative effect on the prognosis of epilepsy.

The effect of migraine on the prognosis of epilepsy has not been reported. The
aim of this prospective 5–10-year follow-up study was to examine some outcome
measures and the cumulative probability of being seizure-free in epilepsy patients
with migraine, and to compare their results with those of epilepsy patients with-out migraine. Fifty-nine patients (40 women; mean age 25 years) were diagnosed
with both epilepsy and migraine (EM group). The control group consisted of 56
patients with epilepsy but without migraine (E group). Both groups were recruited
and followed up over similar periods. We compared the outcome variables in the
EM group with those in the E group. Kaplan–Meier methods were used to assess
the seizure-free curves.The EM group had a significantly lower cumulative prob-ability of being seizure-free over 10 years compared with the E group. The other
epilepsy outcome measures at follow-up differed significantly between the
groups, with the EM group having a longer duration of epilepsy, a lower early
treatment response, and a higher incidence of intractable epilepsy and achieving
remission with polytherapy, and more seizure control and medication problems
for at least the last 2 years of follow-up. Comorbid migraine had a negative effect
on the prognosis of epilepsy.Epilepsy, migraine, prognosis