Predictors of poor kidney outcome in children with C3 glomerulopathy

Pinarbasi A. S., DURSUN İ., GÖKCE İ., ÇOMAK E., Saygili S., BAYRAM M. T., ...Daha Fazla

PEDIATRIC NEPHROLOGY, cilt.36, sa.5, ss.1195-1205, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 5
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1007/s00467-020-04799-7
  • Dergi Adı: PEDIATRIC NEPHROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.1195-1205
  • Anahtar Kelimeler: C3 glomerulopathy, Children, CKD stage 5, Complement, Predictors
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Background C3 glomerulopathy (C3G) is characterized by heterogeneous clinical presentation, outcome, and predominant C3 accumulation in glomeruli without significant IgG. There is scarce outcome data regarding childhood C3G. We describe clinical and pathological features, treatment and outcomes, and risk factors for progression to chronic kidney disease stage 5 (CKD5) in the largest pediatric series with biopsy-proven C3G.