Predictors of poor kidney outcome in children with C3 glomerulopathy

Pinarbasi A. S., DURSUN İ., GÖKCE İ., ÇOMAK E., Saygili S., BAYRAM M. T., ...More

PEDIATRIC NEPHROLOGY, vol.36, no.5, pp.1195-1205, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 5
  • Publication Date: 2021
  • Doi Number: 10.1007/s00467-020-04799-7
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.1195-1205
  • Keywords: C3 glomerulopathy, Children, CKD stage 5, Complement, Predictors
  • Karadeniz Technical University Affiliated: Yes


Background C3 glomerulopathy (C3G) is characterized by heterogeneous clinical presentation, outcome, and predominant C3 accumulation in glomeruli without significant IgG. There is scarce outcome data regarding childhood C3G. We describe clinical and pathological features, treatment and outcomes, and risk factors for progression to chronic kidney disease stage 5 (CKD5) in the largest pediatric series with biopsy-proven C3G.