In this paper, the analysis of hyperbolic cooling tower on elastic subsoil exposed to unsymmetrical wind loading is presented. Modified Vlasov foundation model is used to determine the soil parameters as a function of vertical deformation profile within subsoil. The iterative parameter updating procedure involves the use of Open Application Programming Interface (OAPI) feature of SAP2000 to provide two way data flow during execution. A computing tool coded in MATLAB employing OAPI is used to perform the analysis of hyperbolic cooling tower with supporting columns over a hollow annular raft founded on elastic subsoil. The analysis of such complex soil-structure system is investigated under self-weight and unsymmetrical wind load. The response of the cooling tower on elastic subsoil is compared with that of a tower that its supporting raft foundation is treated as fixed at the base. The results show that the effect of subsoil on the behavior of cooling tower is considerable at the top and bottom of the wall as well as supporting columns and raft foundation. The application of a full-size cooling tower has demonstrated that the procedure is simple, fast and can easily be implemented in practice.