The novel ischemia marker 'ischemia-modified albumin' is increased in normal pregnancies

GÜVEN S., ALVER A., MENTEŞE A., Ilhan F. C., CALAPOĞLU M., Unsal M. A.

ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, cilt.88, sa.4, ss.479-482, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 88 Sayı: 4
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1080/00016340902777517
  • Dergi Adı: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.479-482
  • Anahtar Kelimeler: Albumin, ischemia-modified albumin, maternal serum, malondialdehyde, pregnancy, LIPID PEROXIDES, 1ST-TRIMESTER, PREECLAMPSIA, BINDING
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

The aim of this prospective case-control study was to determine the change in serum maternal ischemia-modified albumin (IMA) during normal pregnancies. A total of 117 pregnant (first trimester (n=24), second trimester (n=34), and third trimester (n=35)) and non-pregnant healthy women (n=23) were included. Maternal serum IMA, Malondialdehyde (MDA), and albumin levels were measured. Compared with non-pregnant women, the cross-sectional mean IMA levels in pregnant women were significantly increased, while the mean serum MDA and albumin levels were significantly decreased throughout pregnancy. Furthermore, a significant negative correlation between serum IMA and albumin levels (r=-0.354, p0.001) was found, and there was a weak positive correlation between serum albumin and MDA levels (r=0.334, p0.001). Serum IMA, which has recently been developed as a clinical marker of ongoing myocardial ischemia, appears to be elevated in normal pregnancy. This may be due to the physiologic oxidative stress state of pregnancy.