Synthesis, configuration, and antimicrobial properties of novel substituted and cyclized '2 ',3 ''-thiazachalcones'

USTA A., Yasar A., YILMAZ N., GUELEC C., Yayh N., KARAOGLU S. A., ...Daha Fazla

HELVETICA CHIMICA ACTA, cilt.90, sa.8, ss.1482-1490, 2007 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 90 Sayı: 8
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1002/hlca.200790154
  • Dergi Adı: HELVETICA CHIMICA ACTA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1482-1490
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Nine new thiazachalcone-based drugs, compounds I - 9, were prepared and fully characterized. The configurations of the photochemical -dimerization products 7-9 were rationalized by semi-empirical calculations. Both the experimental data and the theoretical calculations showed that the delta-truxinic acid type dimer is the most stable isomer of all. All compounds were tested for their antibacterial and antifungal activities. The N-alkylated congeners 4-6 showed strong antimicrobial activities against various bacteria and a yeast-like fungus. The MIC and MBC values were as low as 0.1 mu g/ml. All the compounds were active against the Gram-positive bacterium Staphylococcus aureas.