Total monoamine oxidase (MAO) inhibition by chestnut honey, pollen and propolis

YILDIZ O., Karahalil F., Can Z., ŞAHİN H. İ., KOLAYLI S.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, cilt.29, sa.5, ss.690-694, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 5
  • Basım Tarihi: 2014
  • Doi Numarası: 10.3109/14756366.2013.843171
  • Dergi Adı: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.690-694
  • Anahtar Kelimeler: Honey, monoamine oxidase, pollen, propolis, spectrophotometric peroxidase linked assay, ANTIOXIDANT ACTIVITY, BEE POLLEN, CHEMICAL-COMPOSITION, CARBONIC-ANHYDRASE, EXTRACT, PLANTS, TURKEY, ASSAY
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Monoamine oxidase (MAO) inhibitors are generally used in the treatment of depressive disorders and some neurodegenerative illnesses, such as Parkinson's disease and Alzheimer's disease. The aim of this preliminary study was to investigate the MAO [MAO (E.C.1.4.3.4)] inhibiting effect of various apitherapeutic products, such as chestnut honey, pollen and propolis. Extracts' MAO inhibition was measured using peroxidase-linked spectrophotometric assay in enzyme isolated from rat liver microsomes, and the values are expressed as the inhibition concentration (IC50) causing 50% inhibition of MAO. The antioxidant activity of the bee products was also determined in terms of total phenolic content (TPC) and ferric reducing/antioxidant power in aquatic extracts. All samples exhibited substantial inhibition of MAO, propolis having the highest. Inhibition was related to samples' TPCs and antioxidant capacities. These results show that bee products possess a sedative effect and may be effective in protecting humans against depression and similar diseases.