Akademik Veri Yönetim Sistemi
INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY, 2024 (ESCI)
Estimation of cardiovascular (CV) individual risk over a 10 year period was provide benefit most from preventive action in individual at high risk of CVD, and it evaluated by SCORE2 predictive model. Oxidative stress plays a critical role in all stages of atherosclerosis. It was examined the relationship between oxidative stress and SCORE2, and to investigate whether one of the oxidative stress parameters may represent a potential risk marker permitting more accurate high-risk prediction for CV risk calculation models. The study groups consisted of 71 coronary artery disease (CAD)(-) patients (27 normocholesterolemic and 44 hypercholesterolemic) and 12 CAD(+) patients. Ox-LDL, MDA, OSI, 3-NT, 8-OHdG, and total thiols were measured as oxidative stress parameters and TNF-alpha and IL-6 as inflammatory factors. The oxidative stress parameters were showed significant changes among study groups. ROC analysis identified ox-LDL levels as one of the highest values (AUC:0.998, p < 0.001). ox-LDL exhibited the highest odds ratio at 1.68 (CI = 1.26-2.14) with SCORE2. ox-LDL levels increased significantly and gradually from the low- to high-risk groups of SCORE2 and exhibited the strongest correlation with SCORE2 (r = 0.48, p < 0.001). We suggest that circulating ox-LDL levels may be considered as a candidate marker for more accurate high-risk prediction with SCORE2.