The Association Between Serum Uric Acid Level and Prognosis in Critically Ill Patients, Uric Acid as a Prognosis Predictor

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Pehlivanlar-Kucuk M., Kucuk A. O., Ozturk C. E., Er M. C., ÜLGER F.

CLINICAL LABORATORY, vol.64, no.9, pp.1491-1500, 2018 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 64 Issue: 9
  • Publication Date: 2018
  • Doi Number: 10.7754/clin.lab.2018.180334
  • Journal Name: CLINICAL LABORATORY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1491-1500
  • Keywords: ARDS, intensive care unit, mortality, sepsis, uric acid, RESPIRATORY-DISTRESS-SYNDROME, ANTIOXIDANT CAPACITY, XANTHINE-OXIDASE, MORTALITY, SEVERITY, OXYGEN
  • Open Archive Collection: AVESIS Open Access Collection
  • Karadeniz Technical University Affiliated: Yes

Abstract

Background: Uric acid is synthesized from xanthine via xanthine oxidase as an end-product of purine metabolism. Uric acid is a major non-enzymatic antioxidant in the blood, and it exerts a protective action on vitamin C. There are a limited number of ICU studies related to uric acid, which is a valuable prognostic biomarker. This study aimed to evaluate the utility of uric acid as a biomarker in predicting the outcomes of critically ill patients.