The effects of valproate and topiramate use on serum insulin, leptin, neuropeptide Y and ghrelin levels in epileptic children

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CICEK N. P., Kamasak T., Serin M., Ökten A. N., ALVER A., CANSU A.

SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, vol.58, pp.90-95, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 58
  • Publication Date: 2018
  • Doi Number: 10.1016/j.seizure.2018.03.013
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.90-95
  • Keywords: Valproic acid, Topiramate, Antiepileptic drugs, Endocrine side-effect, Insulin, Glucose, Leptin, NPY, Ghrelin, WEIGHT-GAIN, ACID, THERAPY, GIRLS, CARBAMAZEPINE, RESISTANCE
  • Karadeniz Technical University Affiliated: Yes


Purpose: Although some drugs used in the treatment of epilepsy are known to affect body weight, the hormonal factors responsible have not been sufficiently described. The purpose of this study was to compare insulin, leptin, neuropeptide Y and ghrelin levels in children with epilepsy receiving monotherapy with topiramate (TPM) and valproic acid (VPA), the drugs whose effects on body weight have been most discussed, with those of a control group.