The effects of valproate and topiramate use on serum insulin, leptin, neuropeptide Y and ghrelin levels in epileptic children

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CICEK N. P., Kamasak T., Serin M., Ökten A. N., ALVER A., CANSU A.

SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, cilt.58, ss.90-95, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 58
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.seizure.2018.03.013
  • Dergi Adı: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.90-95
  • Anahtar Kelimeler: Valproic acid, Topiramate, Antiepileptic drugs, Endocrine side-effect, Insulin, Glucose, Leptin, NPY, Ghrelin, WEIGHT-GAIN, ACID, THERAPY, GIRLS, CARBAMAZEPINE, RESISTANCE
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Purpose: Although some drugs used in the treatment of epilepsy are known to affect body weight, the hormonal factors responsible have not been sufficiently described. The purpose of this study was to compare insulin, leptin, neuropeptide Y and ghrelin levels in children with epilepsy receiving monotherapy with topiramate (TPM) and valproic acid (VPA), the drugs whose effects on body weight have been most discussed, with those of a control group.