Akademik Veri Yönetim Sistemi
15.TIP BİLİŞİMİ KONGRESİ, Trabzon, Türkiye, 30 - 31 Mayıs 2024, ss.74-75
B cells play a crucial role in adaptive immune responses by producing antibodies that target specific antigens. The identification of B cell epitopes,
which are the specific regions on antigens recognized by B cell receptors, is essential for understanding immune responses and developing vaccines. In this
study, the most suitable vaccine candidates were predicted for five separate
epitope regions that can be used in vaccine development using B cell epitope
prediction methods. A total of 98 B cell epitopes were identified in the SARSCoV-2 spike protein from the literature and relevant databases. Among them, 5
epitopes met the accessibility criteria and had accessible residues. The longest
accessible subsequences ranged from 4 to 10 amino acids, with an average length
of 4.75 amino acids. Additionally, 25% of the accessible residues con- tained
polymorphic sites, and 75% overlapped with known protein domains. We also
highlight the potential of B cell epitope candidates prediction to con- tribute to
new vaccine design strategies and personalized medicine for future vi- rus
outbreaks such as SARS-CoV-2. Our findings also suggest that B cell epitope
prediction could have a positive impact on developing rapid and effec- tive
vaccine strategies for future virus outbreaks. This study demonstrates that B cell
epitope prediction could be a significant tool in vaccine development against
pathogens with pandemic potential, especially those like SARS-CoV-2.