Association Between Serum Vitamin D. Levels, Clinical Disease Activity and Magnetic Resonance Imaging Lesion Burden in Pediatric Chronic Recurrent Multifocal Osteomyelitis Zusammenhang zwischen Serum-Vitamin-D-Spiegeln, klinischer Krankheitsaktivität und der MRT-Läsionslast bei pädiatrischer chronisch-rezidivierender multifokaler Osteomyelitis
Klinische Padiatrie, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Basım Tarihi: 2026
- Doi Numarası: 10.1055/a-2859-0223
- Dergi Adı: Klinische Padiatrie
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
- Anahtar Kelimeler: chronic recurrent multifocal osteomyelitis, clinical disease activity score, inflammation, magnetic resonance imaging, vitamin D
- Karadeniz Teknik Üniversitesi Adresli: Evet
Özet
Background Chronic recurrent multifocal osteomyelitis is a rare autoinflammatory bone disorder in children. Vitamin D regulates immune and inflammatory pathways, but its impact on chronic recurrent multifocal osteomyelitis remains unclear. This study investigated the relationship between serum 25-hydroxyvitamin D levels and clinical, laboratory, and radiological characteristics of pediatric chronic recurrent multifocal osteomyelitis. Methods Pediatric chronic recurrent multifocal osteomyelitis patients and age- and sex-matched healthy controls were retrospectively evaluated. Serum 25-hydroxyvitamin D, inflammatory markers, clinical disease activity score, and whole-body magnetic resonance imaging findings were analyzed. Results Thirty-one chronic recurrent multifocal osteomyelitis patients and 31 controls were included. Chronic recurrent multifocal osteomyelitis patients had significantly lower 25-hydroxyvitamin D levels and a higher frequency of vitamin D deficiency (p<0.001). Serum 25-hydroxyvitamin D levels showed no correlation with C-reactive protein, erythrocyte sedimentation rate, or the neutrophil-to-lymphocyte ratio, but were inversely correlated with the clinical disease activity score (r=−0.429 andp=0.020) and the number of magnetic resonance imaging-detected skeletal lesions (r=−0.376 andp=0.044). Logistic regression confirmed vitamin D deficiency as independently associated with chronic recurrent multifocal osteomyelitis (odds ratio=0.59, 95% confidence interva: 0.41–0.88, andp=0.007). Conclusions Vitamin D deficiency is highly prevalent in pediatric chronic recurrent multifocal osteomyelitis and correlates with disease severity, reflected by clinical activity and lesion burden, independent of systemic inflammation. These findings suggest vitamin D as a potential biomarker in chronic recurrent multifocal osteomyelitis and highlight the need for prospective studies assessing its therapeutic role.