Synthesis of Novel Pyrazolines, Their Boron-Fluorine Complexes, and Investigation of Antibacterial, Antioxidant, and Enzyme Inhibition Activities
ARCHIV DER PHARMAZIE, vol.350, no.2, 2017 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 350 Issue: 2
- Publication Date: 2017
- Doi Number: 10.1002/ardp.201600285
- Journal Name: ARCHIV DER PHARMAZIE
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Keywords: Azachalcone, Azaflavone, BOAPPY, BODAF, Pyrazoline, MICROWAVE-ASSISTED SYNTHESIS, BIOLOGICAL EVALUATION, ANTIAMEBIC ACTIVITY, IN-VITRO, DERIVATIVES, TYROSINASE, ANTIDEPRESSANT, EXTRACTS, DESIGN, IDENTIFICATION
- Karadeniz Technical University Affiliated: Yes
Abstract
3,5-disubstituted-2-pyrazoline derivatives (4-6), their boron-fluorine complexes (boron (3-(2'-aminophenyl), 5-(2'-/3'-/4'-pyridyl) pyrazoline, BOAPPY) (7-9) and boron 1,2'-diazaflavone complex (BODAF) (11) were synthesized starting from azachalcones (1-3) to diazaflavone (10), respectively. Biological evaluation of compounds 4-9 and 11 showed remarkable antioxidant, antibacterial, and acetylcholinesterase and tyrosinase enzyme inhibition activities. All newly synthesized compounds 4-9 and 11 showed respectable antibacterial effect with minimum inhibitory concentrations in the range of 4.7-150mg/mL.