Synthesis of Novel Pyrazolines, Their Boron-Fluorine Complexes, and Investigation of Antibacterial, Antioxidant, and Enzyme Inhibition Activities

KAHRİMAN N., HAŞİMOĞLU Z., SERDAROĞLU V., BERİŞ F. S., Barut B., YAYLI N.

ARCHIV DER PHARMAZIE, cilt.350, sa.2, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 350 Sayı: 2
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1002/ardp.201600285
  • Dergi Adı: ARCHIV DER PHARMAZIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Azachalcone, Azaflavone, BOAPPY, BODAF, Pyrazoline, MICROWAVE-ASSISTED SYNTHESIS, BIOLOGICAL EVALUATION, ANTIAMEBIC ACTIVITY, IN-VITRO, DERIVATIVES, TYROSINASE, ANTIDEPRESSANT, EXTRACTS, DESIGN, IDENTIFICATION
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

3,5-disubstituted-2-pyrazoline derivatives (4-6), their boron-fluorine complexes (boron (3-(2'-aminophenyl), 5-(2'-/3'-/4'-pyridyl) pyrazoline, BOAPPY) (7-9) and boron 1,2'-diazaflavone complex (BODAF) (11) were synthesized starting from azachalcones (1-3) to diazaflavone (10), respectively. Biological evaluation of compounds 4-9 and 11 showed remarkable antioxidant, antibacterial, and acetylcholinesterase and tyrosinase enzyme inhibition activities. All newly synthesized compounds 4-9 and 11 showed respectable antibacterial effect with minimum inhibitory concentrations in the range of 4.7-150mg/mL.