Biscarbazole Derivatives: Synthesis, Characterization, Antimicrobial and Antitumor Activity, and Molecular Docking Study

Çelik F., Aydın A., İnan Bektaş K., Güler H. İ., Nalçaoğlu A., Ünver Y.

RUSSIAN JOURNAL OF GENERAL CHEMISTRY, cilt.92, sa.10, ss.2145-2160, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 92 Sayı: 10
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1134/s1070363222100279
  • Dergi Adı: RUSSIAN JOURNAL OF GENERAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Index Chemicus (IC)
  • Sayfa Sayıları: ss.2145-2160
  • Anahtar Kelimeler: carbazole, amine, imine, antimicrobial activity, antitumor activity, docking study, SCHIFF-BASE, CARBAZOLE, INHIBITION
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

New series of biscarbazole derivatives containing imine-amine groups was synthesized. Antimicrobial activity of newly synthesized compounds against bacterial strains and yeast isolates was determined. The effects of the synthesized test compounds on cell proliferation and NCI-60 survival parameter values were measured. In addition, in silico analysis against five different receptors with synthesized two compounds was carried out to see the necessary interactions responsible for anti-bacterial activity. The docking results of both compounds supported the antibacterial activity exhibiting high inhibition constants.