Mitral Annular Calcification Is Associated with Pulse Wave Velocity but Not with Augmentation Index

DURMUŞ İ., KARAMAN K., Ozturk S., KUTLU M.

MEDICAL PRINCIPLES AND PRACTICE, cilt.22, sa.2, ss.150-155, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 2
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1159/000343166
  • Dergi Adı: MEDICAL PRINCIPLES AND PRACTICE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.150-155
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Objective: To investigate the possible relationship between mitral annular calcification (MAC) and arterial stiffness. Subjects and Methods: Forty-two patients (mean age 68 8 6 years) with MAC and an age-matched control group of 41 individuals (mean age 66 8 6 years) were studied. Arterial stiffness and wave reflections of the study population were evaluated by using applanation tonometry (SphygmoCor). Aortic pulse wave velocity (PWV) was measured as an index of aortic stiffness. The heart rate-corrected augmentation index (AIx @ 75) was estimated as a composite marker of wave reflections and arterial stiffness. Results: Aortic PWV was significantly higher in patients with MAC (12.2 +/- 2.3 m/s) than in controls (10.1 +/- 1.3 m/s, p = 0.0001). However, AIx @ 75 was similar between the groups (28 +/- 10 vs. 29 +/- 10%, p = 0.59). Multivariate analysis involving the whole population revealed that brachial diastolic blood pressure (beta = 1.87, p = 0.04) and MAC (beta = 0.41, p = 0.0001) were independent determinants of aortic PWV. Conclusion: The data showed that MAC was significantly associated with increased arterial stiffness and that it was an independent determinant of aortic PWV. Copyright (C) 2012 S. Karger AG, Basel