The clinical use of ultra-Wide field imaging and intravenous fluorescein angiography in infants with retinopathy of prematurity

Gunay M. , Tugcugil E. , Somuncu A. M. , Kola M., Turk A., Uzlu D., ...More

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, vol.37, 2022 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 37
  • Publication Date: 2022
  • Doi Number: 10.1016/j.pdpdt.2021.102658
  • Keywords: Angiography, Imaging, Intravenous, Retinopathy of prematurity, Ultra, wide field, AGGRESSIVE POSTERIOR RETINOPATHY, ENDOTHELIAL GROWTH-FACTOR, INTRAVITREAL BEVACIZUMAB, TYPE-1 RETINOPATHY


Purpose: To investigate the potential benefits and practicality of ultra - wide field (UWF) imaging and intravenous UWF fluorescein angiography (IV UWF - FA) in infants with retinopathy of prematurity (ROP) using an Optos (R) California device. Methods: This retrospective study involved 46 infants with a history of ROP who underwent UWF imaging with or without IV UWF - FA. ROP characteristics were identified using UWF color imaging. Retinal vascular findings following treatment were also assessed at IV UWF - FA analysis. All imaging sessions were performed under topical anesthesia without sedation. Main outcomes were the appearance of ROP at UWF color imaging and IV UWF-FA analysis, including status of ROP, neovascularizations, presence of plus disease, retinal vascular details, and resolution after treatment. Results: Seven (three girls) of the 46 infants (22 girls) underwent IV UWF-FA. Twelve IV UWF-FA sessions were performed in total. The oldest infant during IV UWF-FA analysis was at 55 postmenstrual weeks. Clinical characteristics of disease were easily identified at UWF color imaging. IV UWF-FA images also clearly revealed non-perfused retinal areas, fluorescein leakage, macular edema, retinal vascular abnormalities, and the status of the peripheral vascular termini. Complications of IV UWF-FA occurred in one infant in the form of patchy yellow skin discoloration around the injection site which completely disappeared on the first day following the procedure. Conclusions: Providing a high resolution panoramic view of the retina in a single image capture with no need for contact with the cornea appear to represent potential advantages of UWF imaging in infants with ROP. IV UWF-FA also seems to be a safe procedure which can be performed under topical anesthesia and that shows detailed retinal vascular alterations in patients with ROP.