The effects of dabigatran etexilate on fracture healing in rats An experimental study

KERİMOĞLU S., ONAY A., GUVERCIN Y., Citlak A., YENİLMEZ E., KERİMOĞLU G.

INDIAN JOURNAL OF ORTHOPAEDICS, vol.49, no.3, pp.357-360, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 3
  • Publication Date: 2015
  • Doi Number: 10.4103/0019-5413.156227
  • Journal Name: INDIAN JOURNAL OF ORTHOPAEDICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.357-360
  • Karadeniz Technical University Affiliated: Yes

Abstract

Background: Deep vein thrombosis leading to pulmonary embolism is one of the major complication after fracture. After a fracture occurs, the coagulation cascade activates thrombin, a protease that finally generates clotting. Dabigatran etexilate reduce clot formation by inhibiting thrombin. Dabigatran etexilate is a widely used drug for thromboprophylaxis. There is no study of the effects of dabigatran etexilate on fracture healing in the literature, so we aimed to evaluate the effects of dabigatran etexilate on fracture healing.