The effects of dabigatran etexilate on fracture healing in rats An experimental study

KERİMOĞLU S., ONAY A., GUVERCIN Y., Citlak A., YENİLMEZ E., KERİMOĞLU G.

INDIAN JOURNAL OF ORTHOPAEDICS, cilt.49, sa.3, ss.357-360, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 49 Sayı: 3
  • Basım Tarihi: 2015
  • Doi Numarası: 10.4103/0019-5413.156227
  • Dergi Adı: INDIAN JOURNAL OF ORTHOPAEDICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.357-360
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Background: Deep vein thrombosis leading to pulmonary embolism is one of the major complication after fracture. After a fracture occurs, the coagulation cascade activates thrombin, a protease that finally generates clotting. Dabigatran etexilate reduce clot formation by inhibiting thrombin. Dabigatran etexilate is a widely used drug for thromboprophylaxis. There is no study of the effects of dabigatran etexilate on fracture healing in the literature, so we aimed to evaluate the effects of dabigatran etexilate on fracture healing.