Evaluation of Insulin Resistance Measurement Methods in Patients with Polycystic Ovary Syndrome


BİLGİNER M. C., TÜFEKÇİ D., GÜNAY Y. E., USTA O., COŞKUN H., ÜÇÜNCÜ Ö., ...More

Türkiye Diyabet ve Obezite Dergisi , vol.6, no.1, pp.24-31, 2022 (Peer-Reviewed Journal) identifier

Abstract

Aim: This study aims to compare insulin resistance (IR) measurement methods in women with and without polycystic ovary syndrome (PCOS) who have the same body mass index. Material and Methods: There were 84 women with PCOS and non-PCOS (n=18 normal weight and n=24 overweight/obese in both groups). Triglyceride glucose index (TyG), assessment of insulin resistance with homeostasis model (HOMA-IR), visceral adiposity index (VAI) were calculated using lipid level, glucose level and anthropometric measurements. Mann-Whitney U or Student's t-test was used to compare measurements between the groups. The relationship between HOMA-IR and age was calculated with the Pearson correlation test, and the relationship between HOMA-IR and TyG was calculated with the Spearman correlation test. p<0.05 was considered significant. Results: Triglyceride levels, insulin, TyG, and HOMA-IR were higher in the PCOS group than in the non-PCOS group (p=0.003, p=0.001, p=0.006, p=0.001, respectively). In the PCOS group, there was a negative correlation between HOMA-IR and age (r=-0.399, p=0.024), and a positive correlation between HOMA-IR and TyG index (r=0.776, p<0.001). TyG index and HOMA-IR were higher in normal weight PCOS women than non-PCOS (p=0.002, p=0.003, respectively), however there was no difference in overweight/obese PCOS women and non-PCOS. In PCOS patients, a TyG index >3.91 (89.5% sensitivity, 76.9% specificity) predicted insulin resistance (IR). Conclusion: TyG and HOMA-IR levels are higher in women with PCOS than non-PCOS. The TyG index can be used as an alternative method in evaluating insulin resistance among these patients.