A retrospective comparison of concurrent 5-fluoro-uracil or oral UFT in postoperative chemoradiation for gastric adenocarsinoma

Yoney A., BATI Y., AKBORU H., ISIKLI L., UNSAL M. A.

CANCER RADIOTHERAPIE, cilt.14, sa.1, ss.19-23, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 1
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.canrad.2009.09.004
  • Dergi Adı: CANCER RADIOTHERAPIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.19-23
  • Karadeniz Teknik Üniversitesi Adresli: Hayır

Özet

Purpose. - 5-fluoro-uracil (FU) is a common agent in postoperative chemoradiation in gastric adenocarcinoma. However, FU is not well tolerated in a significant proportion of patients. UFT, a fixed combination of the oral FU prodrug tegafur with uracil, is one of the agents used instead of FU in such cases. We retrospectively compared the toxicity, local and distant control and Survival rates with FU or oral UFT during concurrent radiotherapy to assess the role of UFT instead of FU.