Research Information System
JOURNAL OF RESEARCH IN PHARMACY, vol.28, no.6, pp.2008-2016, 2024 (ESCI)
The aim of this study is to determine the protective effects of lupeol on acute exhaustive exercise-induced oxidative stress in male rats.Rats were randomly selected and divided into four groups (n=6/group): Control, exercise, lupeol and exercise+lupeol groups. At the end of the exercise protocol, the rats were sacrificed by cervical dislocation, blood samples were taken. The levels of superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), glutathione (GSH), coenzyme Q10 (CoQ10) and alpha-lipoic acid (ALA) and oxidative stress levels in serum samples were measured.As a result, it has been determined that lupeol, a natural triterpenoid compound, contributes positively to the level of antioxidants produced by the body and helps suppress oxidants. It has been observed that free radicals caused by oxidative stress that occur as a result of high-intensity exercise are reduced by lupeol. Accordingly, it has been determined that the use of lupeol during exercise in experimental animals exposed tooxidative stress inhibits free radicals formed by stress.In the light of these results, it is thought that lupeol may be included in the composition of pharmaceutical products against exercise-induced oxidative damage