Newly Synthesized <i>N</i>-Glycosidic Halochalcones Reveal Inhibitory Activity on Pancreatic Triacylglycerol Lipase

Yikilmaz M., Fandakli S., ŞENER S. Ö., BADEM M., KANBOLAT Ş., YAYLI N., ...Daha Fazla

CHEMISTRY OF NATURAL COMPOUNDS, cilt.59, sa.4, ss.629-637, 2023 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 59 Sayı: 4
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1007/s10600-023-04075-8
  • Dergi Adı: CHEMISTRY OF NATURAL COMPOUNDS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, Chemical Abstracts Core, Veterinary Science Database
  • Sayfa Sayıları: ss.629-637
  • Anahtar Kelimeler: acetyl-N-glucosidic halochalcone, halochalcone, lipase, N-glycosidic halochalcone, obesity
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

In this study, the aim was to synthesize N-glycosidic halochalcone derivatives and to examine their lipase inhibitory activity. The synthesized chalcones (1-3) were well known and the data were compatible with previous findings. However, compounds 4a/b, 5a/b, 6a/b, and 7-9 were synthesized for the first time in the current study. Remarkable lipase inhibitory potentials of the synthesized compounds were further confirmed through molecular docking studies. The highest lipase inhibition activity was experimentally identified for compounds 2 and 5a with IC50 17.7133 & PLUSMN; 0.9648 & mu;g/mL and IC50 22.6521 & PLUSMN; 1.2146 & mu;g/mL, respectively.