Newly Synthesized <i>N</i>-Glycosidic Halochalcones Reveal Inhibitory Activity on Pancreatic Triacylglycerol Lipase

Yikilmaz M., Fandakli S., ŞENER S. Ö., BADEM M., KANBOLAT Ş., YAYLI N., ...More

CHEMISTRY OF NATURAL COMPOUNDS, vol.59, no.4, pp.629-637, 2023 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 59 Issue: 4
  • Publication Date: 2023
  • Doi Number: 10.1007/s10600-023-04075-8
  • Journal Name: CHEMISTRY OF NATURAL COMPOUNDS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, Chemical Abstracts Core, Veterinary Science Database
  • Page Numbers: pp.629-637
  • Keywords: acetyl-N-glucosidic halochalcone, halochalcone, lipase, N-glycosidic halochalcone, obesity
  • Karadeniz Technical University Affiliated: Yes

Abstract

In this study, the aim was to synthesize N-glycosidic halochalcone derivatives and to examine their lipase inhibitory activity. The synthesized chalcones (1-3) were well known and the data were compatible with previous findings. However, compounds 4a/b, 5a/b, 6a/b, and 7-9 were synthesized for the first time in the current study. Remarkable lipase inhibitory potentials of the synthesized compounds were further confirmed through molecular docking studies. The highest lipase inhibition activity was experimentally identified for compounds 2 and 5a with IC50 17.7133 & PLUSMN; 0.9648 & mu;g/mL and IC50 22.6521 & PLUSMN; 1.2146 & mu;g/mL, respectively.