GSPE is superior to NAC in the prevention of contrast-induced nephropathy: Might this superiority be related to caspase 1 and calpain 1?

ULUSOY Ş. , Özkan G., Mungan S. , ÖREM A. , YULUĞ E. , Alkanat M., ...More

LIFE SCIENCES, vol.103, no.2, pp.101-110, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 103 Issue: 2
  • Publication Date: 2014
  • Doi Number: 10.1016/j.lfs.2014.03.030
  • Title of Journal : LIFE SCIENCES
  • Page Numbers: pp.101-110


Aims: Our study was intended to evaluate the role of inducible nitric oxide synthase (iNOS), endothelial nitric oxide synthase (eNOS), caspases 1 and 3 and calpain 1 in the pathogenesis of contrast-induced nephropathy (CIN) and to compare the protective effects of N acetyl cysteine (NAC) and grape seed proanthocyanidin extract (GSPE) against the development of CIN.