GSPE is superior to NAC in the prevention of contrast-induced nephropathy: Might this superiority be related to caspase 1 and calpain 1?

ULUSOY Ş., Özkan G., Mungan S., ÖREM A., YULUĞ E., Alkanat M., ...More

LIFE SCIENCES, vol.103, no.2, pp.101-110, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 103 Issue: 2
  • Publication Date: 2014
  • Doi Number: 10.1016/j.lfs.2014.03.030
  • Journal Name: LIFE SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.101-110
  • Keywords: Contrast-induced nephropathy, Caspases, Calpains, Grape seed proanthocyanidin extract, GSPE, N acetyl cysteine, NAC, N-ACETYLCYSTEINE, CASPASE-1-DEFICIENT MICE, INDUCED APOPTOSIS, RENAL-FUNCTION, HYPOXIA, MEDIA, CELLS
  • Karadeniz Technical University Affiliated: Yes

Abstract

Aims: Our study was intended to evaluate the role of inducible nitric oxide synthase (iNOS), endothelial nitric oxide synthase (eNOS), caspases 1 and 3 and calpain 1 in the pathogenesis of contrast-induced nephropathy (CIN) and to compare the protective effects of N acetyl cysteine (NAC) and grape seed proanthocyanidin extract (GSPE) against the development of CIN.