LIFE SCIENCES, vol.103, no.2, pp.101-110, 2014 (Peer-Reviewed Journal)
Article / Article
Science Citation Index Expanded, Scopus
Contrast-induced nephropathy, Caspases, Calpains, Grape seed proanthocyanidin extract, GSPE, N acetyl cysteine, NAC, N-ACETYLCYSTEINE, CASPASE-1-DEFICIENT MICE, INDUCED APOPTOSIS, RENAL-FUNCTION, HYPOXIA, MEDIA, CELLS
Aims: Our study was intended to evaluate the role of inducible nitric oxide synthase (iNOS), endothelial nitric oxide synthase (eNOS), caspases 1 and 3 and calpain 1 in the pathogenesis of contrast-induced nephropathy (CIN) and to compare the protective effects of N acetyl cysteine (NAC) and grape seed proanthocyanidin extract (GSPE) against the development of CIN.