GSPE is superior to NAC in the prevention of contrast-induced nephropathy: Might this superiority be related to caspase 1 and calpain 1?

ULUSOY, ŞÜKRÜ; Özkan, Gulsum; Mungan, SEVDEGÜL; ÖREM, ASIM; YULUĞ, ESİN; Alkanat, Mehmet; YUCESAN, FULYA

doi:10.1016/j.lfs.2014.03.030

GSPE is superior to NAC in the prevention of contrast-induced nephropathy: Might this superiority be related to caspase 1 and calpain 1?

Atıf İçin Kopyala

ULUSOY Ş., Özkan G., Mungan S., ÖREM A., YULUĞ E., Alkanat M., ...Daha Fazla

LIFE SCIENCES, cilt.103, sa.2, ss.101-110, 2014 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 103 Sayı: 2
Basım Tarihi: 2014
Doi Numarası: 10.1016/j.lfs.2014.03.030
Dergi Adı: LIFE SCIENCES
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.101-110
Anahtar Kelimeler: Contrast-induced nephropathy, Caspases, Calpains, Grape seed proanthocyanidin extract, GSPE, N acetyl cysteine, NAC, N-ACETYLCYSTEINE, CASPASE-1-DEFICIENT MICE, INDUCED APOPTOSIS, RENAL-FUNCTION, HYPOXIA, MEDIA, CELLS
Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Aims: Our study was intended to evaluate the role of inducible nitric oxide synthase (iNOS), endothelial nitric oxide synthase (eNOS), caspases 1 and 3 and calpain 1 in the pathogenesis of contrast-induced nephropathy (CIN) and to compare the protective effects of N acetyl cysteine (NAC) and grape seed proanthocyanidin extract (GSPE) against the development of CIN.