In the study, dynamic behavior of laminated orthotropic beams on elastic foundation is investigated. Consistent model presented here combines the finite element solution of the system with SAP2000 software and the calculation of soil parameters with MATLAB software using Modified Vlasov Model type elastic foundation. For this purpose, a computing tool is coded in MATLAB which employs Open Application Programming Interface (OAPI) feature of SAP2000 to provide two-way data flow during execution. Firstly, an example is taken from the literature to demonstrate the accuracy of the consistent FEM-Vlasov Model. Subsequently, the effects of boundary conditions, subsoil depth, elasticity modulus of subsoil, slenderness ratio, velocity of moving load and lamination scheme on the behavior of laminated orthotropic beams on elastic foundation are investigated on a new numerical example. It can be concluded that it is really convenient to use OAPI feature of SAP2000 to model this complex behavior of laminated orthotropic beams on elastic foundation under moving load.