Akademik Veri Yönetim Sistemi
X. INTERNATIONAL HALICH CONGRESS ON MULTIDISCIPLINARY SCIENTIFIC RESEARCH, İstanbul, Türkiye, 4 - 05 Mayıs 2026, ss.117-123, (Tam Metin Bildiri)
An odontogenic keratocyst (OKC) is a developmental odontogenic cyst originating from the dental lamina and is characterized by a distinctive histopathological architecture, an anteroposterior growth pattern, and a high recurrence potential. The presence of multiple OKCs is a significant clinical finding, particularly in young patients, as it may indicate Nevoid Basal Cell Carcinoma Syndrome (Gorlin–Goltz syndrome). This case report presents an adolescent patient presenting with multiple OKCs involving both the maxilla and mandible. Radiographic examination revealed well-defined radiolucent lesions located between the right lateral incisor and canine in the maxilla, as well as around the crowns of impacted third molars in the mandible. Cone-beam computed tomography (CBCT) enabled detailed evaluation of lesion dimensions and their relationship with adjacent anatomical structures. All lesions were treated by surgical enucleation, and histopathological examination confirmed the diagnosis of OKC. No recurrence was observed during the follow-up period. Due to the presence of multiple lesions, genetic analysis was performed and revealed a heterozygous mutation in the PTCH1 gene, consistent with Gorlin–Goltz syndrome. This case underscores the importance of considering syndromic associations in young patients presenting with multiple jaw lesions. It also highlights the necessity of integrating clinical, radiological, and histopathological findings to establish a definitive diagnosis.