Evaluation of the effectiveness of human breast milk exosomes in experimental testicular torsion-detorsion injury model Evaluación de la eficacia de los exosomas de la leche materna humana en un modelo experimental de lesión por torsión-destorsión testicular

Öztürk Ü. T., YALÇIN CÖMERT H. S., ŞALCI G., ALVER A., Mungan S. A., SAĞLAM N., ...Daha Fazla

Cirugia y Cirujanos, cilt.93, sa.2, ss.151-157, 2025 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 93 Sayı: 2
  • Basım Tarihi: 2025
  • Doi Numarası: 10.24875/ciru.23000462
  • Dergi Adı: Cirugia y Cirujanos
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, Directory of Open Access Journals
  • Sayfa Sayıları: ss.151-157
  • Anahtar Kelimeler: Exosome, Ischemia/reperfusion, Testicular torsion
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Objective: Our aim was to examine the effectiveness of human breast milk exosomes in treating testicular torsion. Methods: Rats were divided randomly into three equal groups. Group 1 was our control group. A torsion/detorsion model was created for the rats in Group 2. After the torsion/detorsion model, 1 mg/kg intraperitoneally human breast milk exosomes were given 30 min before detorsion in Group 3. All testicles were removed at the 6th h of the experiment, for biochemical and histopathological examination. Results: There was a statistically significant decrease in Group 3 MDA values compared to Group 2. When Group 3 and Group 2 SOD and CAT values were compared, it was seen that these values were higher in Group 3. Histopathologically a statistically significant difference was found in Group 3 compared to Group 1 and Group 2 in terms of ischemia/reperfusion injury. Conclusion: We have shown that human breast milk exosomes in testicular torsion do not completely prevent reperfusion injury but significantly preserve testicular tissue.