Oral streptococci and cardiovascular disease: Searching for the platelet aggregation-associated protein gene and mechanisms of Streptococcus sanguis-induced thrombosis

Herzberg M., Nobbs A., Tao L., Kilic A. O., Beckman E., Khammanivong A., ...Daha Fazla

JOURNAL OF PERIODONTOLOGY, cilt.76, sa.11, ss.2101-2105, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 76 Sayı: 11
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1902/jop.2005.76.11-s.2101
  • Dergi Adı: JOURNAL OF PERIODONTOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2101-2105
  • Anahtar Kelimeler: cardiovascular disease, genes, platelet aggregation, Streptococcus sanguis, thrombosis, VIRIDANS GROUP STREPTOCOCCI, C-REACTIVE PROTEIN, ENDOTHELIAL-CELLS, TISSUE FACTOR, GLYCOPROTEIN-IB, CORONARY-THROMBOSIS, IMMUNOGLOBULIN-G, ENDOCARDITIS, ENDOTOXEMIA, BINDING
  • Karadeniz Teknik Üniversitesi Adresli: Hayır

Özet

Background: Pathogenic mechanisms in infective endocarditis, disseminated intravascular coagulation, and cardiovascular events involve the aggregation of platelets into thrombi. Attendant infection by oral bacteria contributes to these diseases. We have been studying how certain oral streptococci induce platelet aggregation in vitro and in vivo. Streptococcus sanguis expresses a platelet aggregation-associated protein (PAAP), which contributes little to adhesion to platelets. When specific antibodies or peptides block PAAP, S. sanguis fails to induce platelet aggregation in vitro or in vivo.