Molecular Analysis of Erection Regulatory Factors in Sickle Cell Disease Associated Priapism in the Human Penis

Lagoda G., Sezen S. F., Cabrini M. R., Musicki B., Burnett A. L.

JOURNAL OF UROLOGY, cilt.189, sa.2, ss.762-768, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 189 Sayı: 2
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.juro.2012.08.198
  • Dergi Adı: JOURNAL OF UROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.762-768
  • Anahtar Kelimeler: penis, anemia, sickle cell, priapism, oxidative stress, nitric oxide, NITRIC-OXIDE SYNTHASE, PATHOPHYSIOLOGY, MICE, METABOLITES, DYSFUNCTION, MECHANISM, PATHWAY, KINASE
  • Karadeniz Teknik Üniversitesi Adresli: Hayır

Özet

Purpose: Priapism is a vasculopathy that occurs in approximately 40% of patients with sickle cell disease. Mouse models suggest that dysregulated nitric oxide synthase and RhoA/ROCK signaling as well as increased oxidative stress may contribute to the mechanisms of sickle cell disease associated priapism. We examined changes in the protein expression of nitric oxide synthase and ROCK signaling pathways, and a source of oxidative stress, NADPH oxidase, in penile erectile tissue from patients with a priapism history etiologically related and unrelated to sickle cell disease.