Molecular Analysis of Erection Regulatory Factors in Sickle Cell Disease Associated Priapism in the Human Penis

Lagoda G., Sezen S. F., Cabrini M. R., Musicki B., Burnett A. L.

JOURNAL OF UROLOGY, vol.189, no.2, pp.762-768, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 189 Issue: 2
  • Publication Date: 2013
  • Doi Number: 10.1016/j.juro.2012.08.198
  • Journal Name: JOURNAL OF UROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.762-768
  • Keywords: penis, anemia, sickle cell, priapism, oxidative stress, nitric oxide, NITRIC-OXIDE SYNTHASE, PATHOPHYSIOLOGY, MICE, METABOLITES, DYSFUNCTION, MECHANISM, PATHWAY, KINASE
  • Karadeniz Technical University Affiliated: No

Abstract

Purpose: Priapism is a vasculopathy that occurs in approximately 40% of patients with sickle cell disease. Mouse models suggest that dysregulated nitric oxide synthase and RhoA/ROCK signaling as well as increased oxidative stress may contribute to the mechanisms of sickle cell disease associated priapism. We examined changes in the protein expression of nitric oxide synthase and ROCK signaling pathways, and a source of oxidative stress, NADPH oxidase, in penile erectile tissue from patients with a priapism history etiologically related and unrelated to sickle cell disease.