Akademik Veri Yönetim Sistemi
PLANT FOODS FOR HUMAN NUTRITION, cilt.80, sa.2, 2025 (SCI-Expanded, Scopus)
Trachystemon orientalis (L.) D.Don is a perennial herb extensively utilized for culinary purposes and the treatment of numerous ailments. Hyperlipidemia is a significant risk factor for atherosclerosis, diabetes, obesity, and coronary heart disease. The inhibition of pancreatic lipase (PL) and cholesterol esterase (CE) aims to mitigate problems associated with lipid metabolism disorders by decreasing hyperlipidemia. In this context, enhancing antioxidant capability is an additional objective. This study assessed the PL and CE inhibitory actions of extracts and compounds from the aerial parts of T. orientalis, utilizing ferric reducing antioxidant power (FRAP) and cupric-reducing antioxidant capacity (CUPRAC) assays to measure antioxidant capabilities. Rosmarinic acid, a combination of rosmarinic acid and danshensu (phenolic acids), and beta-sitosterol (phytosterol) were isolated. beta-sitosterol (IC50: 41.698 +/- 1.982 mu g/mL, 14.249 +/- 1.209 mu g/mL, respectively) followed by rosmarinic acid (IC50: 48.213 +/- 2.490 mu g/mL, 21.941 +/- 3.785 mu g/mL, respectively) demonstrated significant inhibitory effects on PL and CE. Additionally, rosmarinic acid (FRAP: 1274.400 +/- 1.633 mu M TEAC, CUPRAC: 1801.389 +/- 5.500 mu M TEAC) and its combination with danshensu (FRAP: 1405.067 +/- 4.491, CUPRAC: 2174.167 +/- 9.647 mu M TEAC) exhibited high antioxidant activity. The ethyl acetate subextract (TOE) from which rosmarinic acid was isolated showed considerable enzyme inhibitory (IC50: 47.577 +/- 0.931 mu g/mL, 12.443 +/- 1.233 mu g/mL, for PL and CE inhibition, respectively) and antioxidant activity (FRAP: 1770.021 +/- 4.583, CUPRAC: 2189.167 +/- 5.401 mu M TEAC). T. orientalis has been identified as a promising natural resource for the management of lipid metabolism-related disorders and for enhancing antioxidant activity.