Papillary Thyroid Cancer is also more common in The Iodine Deficiency area: Evaluation of 2748 Patients


Koçak M., Erbölükbaş G., Nuhoğlu İ., Demir A. S., Ersöz H. Ö.

25th European Congress of Endocrinology 2023, İstanbul, Turkey, 13 - 16 May 2023, vol.90, pp.1034-1035

  • Publication Type: Conference Paper / Summary Text
  • Volume: 90
  • Doi Number: 10.1530/endoabs.90.ep1034
  • City: İstanbul
  • Country: Turkey
  • Page Numbers: pp.1034-1035
  • Karadeniz Technical University Affiliated: Yes

Abstract

Thyroid cancer is the most common malignancy of the endocrine system. Papillary thyroid cancer is the most common thyroid malignancy worldwide and has a good prognosis. The prevalence of follicular thyroid cancer in endemic iodine deficiency regions is higher than in regions without iodine deficiency.However, it has been observed that the incidence of follicular thyroid cancer decreases and the incidence of papillary thyroid cancer increases after iodine prophylaxis. The Our study, 2748 patients (2201 females, 547 males) admitted to the Endocrinology Department of Faculty of Medicine/Karadeniz Technical University between January 1993 and June 2018 were diagnosed as thyroid cancer pathologically. In this study, papillary thyroid cancer was the most common type of thyroid cancer in Trabzon, endemic iodine deficiency region. It was observed that the incidence of thyroid cancer tended to decline after peaking in 2012 according to the years of diagnosis. Of these cases, 2201 (80.1%) were female and 547 (19.9%) were male. Female cases were observed 4 times more. The age range of the cases was 18-89 and the mean age at diagnosis was 48.14 G 12.5. The mean age of the female cases was 47.5G12.8, and the mean age of the male cases was 51.3G11.9. It was observed that female cases were diagnosed at a younger age than males and it was found to be statistically significant (P! 0.001), (Table 9). The cases diagnosed with thyroid cancer histopathologically were divided into 7 diagnostic groups. 1) 2571 Papillary Thyroid Cancer (PTC), 2) 97 Follicular Thyroid Cancer (FTC), 3) 45 Medullary Thyroid Cancer (MTC), 4) 16 Anaplastic thyroid cancer (ATC), 5) 7 Hurthle cell cancer (HTC), 6) 11 Mixed type thyroid cancer (MixedTC) and 7) 1 poorly differentiated carcinoma group (poorly differentiatedTC) (Table 1). PTC was evaluated as two main groups; Those with tumor size less than %10 mm were called papillary microcarcinoma. The distribution of 2542 PTC cases with tumor size in our study; 1238 (48.7%) papillary microcarcinoma, 1304 (51.3%) O1 cm PTC. 83.4% (1032/1238) of cases with papillary microcarcinoma were female, 16.6% (206/1238) were male, 78.3% (1021/1304) of cases with PTC O 1 cm were female, % 21.7 (283/1304) of them are male.