Circulating serum miR-200c and miR-34a-5p as diagnostic biomarkers for endometriosis

MISIR S., Hepokur C., Oksasoglu B., YILDIZ Ç., YANIK A., ALİYAZICIOĞLU Y.

JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION, cilt.50, sa.4, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Sayı: 4
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.jogoh.2021.102092
  • Dergi Adı: JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Endometriosis, Biomarker, Non-invasive diagnosis, miR-34a-5p, miR-200c
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Objective: Endometriosis is defined by the presence of endometrial glands and stroma grow in areas outside the uterus. A simple blood test for endometriosis-specific biomarkers would offer a more timely accurate diagnosis of the disease and could lead to earlier treatment intervention. Alterations in microRNA (miRNA) levels in blood may reflect changes during normal physiologic processes and have been related to several pathologic conditions, including gynecologic diseases. In the present study, we aim to evaluate the level of serum miR-34a-5p and miR-200c from women with and without endometriosis, and to explore the potential of miRNAs as reliable non-invasive biomarkers in the diagnosis of endometriosis.