Akademik Veri Yönetim Sistemi
PLANT BIOSYSTEMS, cilt.0, sa.0, 2026 (SCI-Expanded, Scopus)
Hypericum androsaemum, a member of the genus Hypericum, is traditionally utilized for its wound healing properties and as a herbal tea. This study investigates the antimicrobial activities of its extracts against Gram-positive and Gram-negative bacteria as well as yeast. The antimicrobial efficacy of dichloromethane, methanol, and water extracts from the leaves and fruits of H. androsaemum, was assessed via microdilution and time-kill assays. Results indicated notable inhibitory effects against specific Gram-positive bacteria, particularly Staphylococcus aureus and Staphylococcus epidermidis, with minimum inhibitory concentrations (MICs) of 1.22 μg/mL and 2.44 μg/mL, respectively. Furthermore, biofilm formation assays indicated that selected fruit methanol (FM) and leaves dichloromethane (LD) extracts could hinder bacterial adherence for Staphylococcus strains, thus showing potential as antibiofilm agents. Gas chromatography-mass spectrometry (GC–MS) revealed a diverse fatty acid profile for the two extracts, with key components including linoleic acid (7.84% in LD and 28.916% in FM) and oleic acid (10.953% in LD and 24.270% in FM), which are linked to antimicrobial activity. These findings suggest that H. androsaemum extracts possess significant antimicrobial properties, warranting further research on their potential applications in combating microbial resistance and infections.