Akademik Veri Yönetim Sistemi
Eurasian Clinical and Analytical Medicine, cilt.12, sa.1, ss.10-14, 2024 (ESCI)
Aim: The link between cancer and inflammation is of interest to many researchers. This study aims to determine the relationship between inflammatory parameters (SII, NLR, PLR, and MPV) and diagnostic parameters of 68GaPSMA PET/CT (SUVmax and HU). In addition, we aimed to compare these data with PSA values and metastasis patterns in prostate cancer patients. Material and Methods: Seventy-five prostate cancer patients who were sent to the Nuclear Medicine Department for 68Ga-PSMA PET/CT imaging, who did not undergo a undergo a prostatectomy and radiotherapy, and who had a complete blood count within a few weeks before or after imaging were included in the study. SII, NLR, PLR, and MPV were studied as inflammatory parameters. HU and SUVmax of the areas showing the highest uptake from the tumor areas in the prostate were measured from 68Ga-PSMA PET/CT. Results: Metastasis was present in 58 (77.3%) patients. Lymph node metastasis was found to be more common in patients with SII≥726 and NLR value ≥3 (p=0.007 and 0.025, respectively). According to median MPV values, patients were divided into two groups: patients with MPV values <9.5 and ≥9.5, and diffuse bone metastasis was found to be higher in patients with MPV values <9.5 (p=0.023). Also, a negative correlation was found between MPV values and PSA (p=0.008,r=-0.310). Discussion: A statistically significant relationship between high SII and high NLR values and lymph node metastasis, a negative correlation between MPV and PSA, and a relationship between low MPV values and widespread bone metastasis was found. For this reason, it should be kept in mind during clinical follow-up that PSA levels, as well as hemogram data, carry signs of possible metastasis.