Therapeutic Treatment with Abdominal Adipose Mesenchymal Cells Does Not Prevent Elastase-Induced Emphysema in Rats


Gulhan P. Y. , EKİCİ M. S. , Niyaz M., Gulhan M., ERCİN M. E. , EKİCİ A., ...More

TURKISH THORACIC JOURNAL, vol.21, no.1, pp.14-20, 2020 (Journal Indexed in ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 1
  • Publication Date: 2020
  • Doi Number: 10.5152/turkthoracj.2019.180136
  • Title of Journal : TURKISH THORACIC JOURNAL
  • Page Numbers: pp.14-20

Abstract

OBJECTIVES: Emphysema and chronic bronchitis have different pathophysiologies but both are significant components of chronic obstructive lung disease (COPD). The levels of Matrix metalloproteinase (MMP)-9 in the bronchoalveloar lavage fluid (BALF) and in serum indicate the presence of emphysema. Intratracheal administration of elastase has been used to create a rat model of emphysema. Adipose tissue-derived mesenchymal stem cells (MSC) have been postulated to prevent or reverse emphysema, however, this has not been examined in the rat model of elastase-induced emphysema.