Therapeutic Treatment with Abdominal Adipose Mesenchymal Cells Does Not Prevent Elastase-Induced Emphysema in Rats


Gulhan P. Y. , EKİCİ M. S. , Niyaz M., Gulhan M., ERCİN M. E. , EKİCİ A., ...Daha Fazla

TURKISH THORACIC JOURNAL, cilt.21, ss.14-20, 2020 (ESCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 21 Konu: 1
  • Basım Tarihi: 2020
  • Doi Numarası: 10.5152/turkthoracj.2019.180136
  • Dergi Adı: TURKISH THORACIC JOURNAL
  • Sayfa Sayıları: ss.14-20

Özet

OBJECTIVES: Emphysema and chronic bronchitis have different pathophysiologies but both are significant components of chronic obstructive lung disease (COPD). The levels of Matrix metalloproteinase (MMP)-9 in the bronchoalveloar lavage fluid (BALF) and in serum indicate the presence of emphysema. Intratracheal administration of elastase has been used to create a rat model of emphysema. Adipose tissue-derived mesenchymal stem cells (MSC) have been postulated to prevent or reverse emphysema, however, this has not been examined in the rat model of elastase-induced emphysema.