The diagnostic and prognostic significance of SCUBE1 levels in Crimean-Congo hemorrhagic fever

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MENTEŞE A., YILMAZ G., SUMER A., ARSLAN M., KARAHAN S. C., Koksal I.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, vol.17, no.11, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 11
  • Publication Date: 2013
  • Doi Number: 10.1016/j.ijid.2013.03.014
  • Journal Name: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: SCUBE1, CCHF, Prognostic significance, Hemorrhagic fever, Biomarker, PROTEIN, DOMAIN
  • Karadeniz Technical University Affiliated: Yes

Abstract

Background: The new biochemical marker, signal peptide-CUB-EGF domain-containing protein 1 (SCUBE1), is secreted and cell surface glycoprotein expressed during early embryogenesis. The protein is found in platelet and endothelial cells. Crimean-Congo hemorrhagic fever (CCHF), which is caused by a tick-borne virus belonging to the Bunyaviridae family, may present with a mild clinical course or may exhibit a severe profile with potentially fatal hemorrhaging. The aim of this study was to determine the diagnostic and prognostic significance of SCUBE1 levels in CCHF.