Synthesis and Anti-Biofilm Activity Studies on Novel Quinazolinone-Thiadiazole Hybrids
CLINICAL AND EXPERIMENTAL HEALTH SCIENCES, cilt.15, sa.1, ss.170-174, 2025 (ESCI, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 15 Sayı: 1
- Basım Tarihi: 2025
- Doi Numarası: 10.33808/clinexphealthsci.1548035
- Dergi Adı: CLINICAL AND EXPERIMENTAL HEALTH SCIENCES
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.170-174
- Karadeniz Teknik Üniversitesi Adresli: Evet
Özet
Objective: In this study it was aimed to synthesize novel 1,3,4-thiadizole bearing 4(3H)-quinazolinone compounds, elucidate their structure and evaluate their anti-biofilm activity. Methods: Four novel 4(3H)-quinazolinone compounds (1-4) were synthesized with a two step reaction starting from 5-bromoanthranilic acid. Their anti-biofilm activity was investigated. Results: The final compounds' structures were clarified by elemental analysis and spectroscopic methods (IR, 1H-NMR, 13C-NMR and MS). In the result of anti-biofilm activity studies, they possessed 26.0-30.0% biofilm formation inhibition. Conclusion: Amongthe tested compounds, 6-bromo-3-{4-[5-(4-nitrophenylamino)-1,3,4-thiadiazol-2-yl]phenyl}-2-methylquinazolin-4(3H)-one formulated compound 3 was found as the most active one with 30.0% biofilm formation inhibition.