Development of Highly Sensitive Voltammetric Methods for the Determination of Antihistamine Drug Cetirizine Using A Poly(Bromocresol Purple) Film-Based Electrochemical Sensor


Sofu U., ÖZTÜRK G., REİS H. A., ERDEMİR F., KUL D.

ANALYTICAL LETTERS, 2024 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1080/00032719.2024.2387657
  • Dergi Adı: ANALYTICAL LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Chimica, Communication Abstracts, Food Science & Technology Abstracts, Metadex, Veterinary Science Database, Civil Engineering Abstracts
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Simple and highly sensitive voltammetric methods were developed using a poly(bromocresol purple) modified glassy carbon electrode to quantify cetirizine. Poly(bromocresol purple) film was synthesized on the surface of a glassy carbon electrode by cyclic voltammetry for 50 potential cycles in 0.1 M phosphate buffer at pH 6.0 containing 5.0 x 10-4 M of the monomer. Quantification of cetirizine exhibiting irreversible properties using the optimized conditions with a linear dependence between cetirizine concentration and peak currents from 0.2 to 100 mu M for differential pulse voltammetry (DPV) and 0.1 to 100 mu M for square wave voltammetry (SWV). Detection limits were 21.8 and 15.1 nM for DPV and SWV, respectively. Relative standard deviation (RSD) values below 0.98% indicated good precision. Recovery values from 100.12% to 100.90% with relative standard deviations below 1.14% for DPV and SWV in pharmaceutical formulations and urine samples demonstrated the high accuracy of the developed methods. The prepared modified electrode exhibited good fabrication reproducibility and suitable long-term stability. Finally, no interferences were observed in cetirizine determination in the presence of co-existing substances in the biological samples.