Assessment of acute toxicity and histopathology of the fungicide captan in rainbow trout


Boran H., ÇAPKIN E., ALTINOK İ., Terzi E.

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, vol.64, no.3, pp.175-179, 2012 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 64 Issue: 3
  • Publication Date: 2012
  • Doi Number: 10.1016/j.etp.2010.08.003
  • Journal Name: EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.175-179
  • Keywords: Captan, Rainbow trout, Histopathology, Acute toxicity test, SUBLETHAL CONCENTRATIONS, WATER-QUALITY, FISH SIZE, ENDOSULFAN, GILLS, METHIOCARB, PESTICIDE, PRAWN, LIVER

Abstract

Acute toxicity of the fungicide, captan, to juvenile rainbow trout was evaluated under static-renewal test condition. Actual concentrations of captan ranged from 0.05 to 1.00 mg/L. The concentrations of captan that killed 50% of the rainbow trout (3.11 +/- 0.8g) within 24 (24 h; LC50). 48, 72 and 96 h were 0.57 +/- 0.09, 0.49 +/- 0.10, 0.44 +/- 0.11 and 0.38 +/- 0.13 mg/L(95% confidence limits), respectively. None of the unexposed control fish died and the first fish died 6 h after exposure to captan (>= 0.65 mg/L). Hypertrophy, separation of epithelium from lamellae, lamellar fusion, and epithelial cell necrosis were observed on captan exposed fish. Gills also had scattered areas of focal lamellar hyperplasia. Fish exposed to fungicide had inflammation and necrosis in liver, trunk kidney and spleen. In order, the most affected organs were gill, trunk kidney and liver. (C) 2010 Elsevier GmbH. All rights reserved.