Synthesis, characterization, and antioxidant activities of new trisubstituted triazoles


SANCAK K. , ÜNVER Y. , UNLUER D., DUGDU E., KOR G., ÇELİK F. , ...More

TURKISH JOURNAL OF CHEMISTRY, vol.36, no.3, pp.457-466, 2012 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 3
  • Publication Date: 2012
  • Doi Number: 10.3906/kim-1110-43
  • Title of Journal : TURKISH JOURNAL OF CHEMISTRY
  • Page Numbers: pp.457-466

Abstract

A series of new 4-(3,4dimethoxyphenethyl)-3,5-akyl/aryl-4H-1,2,4-triazoles (3a-g) were obtained by reaction of ethyl N'-(alkylidene/arylidene) hydrazonate (1) and 2-(3,4-dimethoxy phenyl) ethanamine (2). Compounds 4d, e, and g were synthesized from the reaction of corresponding compounds 3d, e, and g with BBr3, respectively. The 10 new compounds synthesized were characterized by elemental analyses, IR, H-1-NMR, and C-13-NMR spectral data. The structure of compound 3g was inferred through IR, H-1-, C-13-NMR, elemental analyses, and X-ray spectral techniques. In addition, the newly synthesized chemicals were screened for their antioxidant properties. Among the chemicals tested, 4d, e, and g exhibited the highest degree of antioxidant activity.