Annual Reports in Medicinal Chemistry


Şöhretoğlu D., Renda G.

Academic Press , Liverpool, 2020

  • Publication Type: Book / Vocational Book
  • Publication Date: 2020
  • Publisher: Academic Press
  • City: Liverpool

Abstract

Osteoporosis is a global health problem, commonly occurring in elderly people, especially in postmenopausal women. Due to ever-increasing aging population and life expectancy, the incidence of osteoporosis is expected to be a bigger problem. Currently, antiresorptive and anabolic agents are used in the clinic for the treatment of osteoporosis. However, these therapies are frequently hampered by severe side effects, especially after long-term use. Hence, finding new, safe and suitable treatment for osteoporosis is a matter of great concern. Medicinal plants can be safe alternatives for current therapies. Numerous plant extracts as well as compounds isolated therefrom were evaluated for their potential for bone-related diseases. Some of them were applied to clinical trials and promising results were obtained. This chapter presents examples to mechanistically well-studied plant-based extracts and natural compounds, which can potentially be effective in the treatment of osteoporosis.