Role of erythropoietin in prevention of amikacin-induced nephropathy.

Kaynar K., ALIYAZIOGLU R., ERSÖZ Ş., Ulusoy S., AL S., Özkan G., ...Daha Fazla

Journal of nephrology, cilt.25, sa.5, ss.744-9, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 5
  • Basım Tarihi: 2012
  • Doi Numarası: 10.5301/jn.5000054
  • Dergi Adı: Journal of nephrology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.744-9
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Background: Aminoglycoside antibiotics are widely used potent bactericidal drugs. However, nephrotoxicity side effects via oxidant injury limit their effectiveness. Erythropoietin (Epo) has been shown to exert pleiotropic effects besides promoting erythrocyte differentiation such as antiapoptotic, antioxidant functions in ischemic and toxic acute renal injury. Therefore we aimed to explore whether Epo is renoprotective in an amikacin-induced nephropathy model in rats.