Role of erythropoietin in prevention of amikacin-induced nephropathy.

Kaynar K., ALIYAZIOGLU R., ERSÖZ Ş., Ulusoy S., AL S., Özkan G., ...More

Journal of nephrology, vol.25, no.5, pp.744-9, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 5
  • Publication Date: 2012
  • Doi Number: 10.5301/jn.5000054
  • Journal Name: Journal of nephrology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.744-9
  • Karadeniz Technical University Affiliated: Yes

Abstract

Background: Aminoglycoside antibiotics are widely used potent bactericidal drugs. However, nephrotoxicity side effects via oxidant injury limit their effectiveness. Erythropoietin (Epo) has been shown to exert pleiotropic effects besides promoting erythrocyte differentiation such as antiapoptotic, antioxidant functions in ischemic and toxic acute renal injury. Therefore we aimed to explore whether Epo is renoprotective in an amikacin-induced nephropathy model in rats.