Role of erythropoietin in prevention of amikacin-induced nephropathy


Kaynar K., ALIYAZIOGLU R., ERSÖZ Ş. , Ulusoy S. , AL S., Özkan G., ...Daha Fazla

JOURNAL OF NEPHROLOGY, cilt.25, ss.744-749, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 25 Konu: 5
  • Basım Tarihi: 2012
  • Doi Numarası: 10.5301/jn.5000054
  • Dergi Adı: JOURNAL OF NEPHROLOGY
  • Sayfa Sayıları: ss.744-749

Özet

Background: Aminoglycoside antibiotics are widely used potent bactericidal drugs. However, nephrotoxicity side effects via oxidant injury limit their effectiveness. Erythropoietin (Epo) has been shown to exert pleiotropic effects besides promoting erythrocyte differentiation such as antiapoptotic, antioxidant functions in ischemic and toxic acute renal injury. Therefore we aimed to explore whether Epo is renoprotective in an amikacin-induced nephropathy model in rats.