Successful use of fondaparinux in a patient with heparin-induced thrombocytopenia while on extracorporeal membrane oxygenation after mitral valve redo surgery


Parlar A. I. , Sayar U., Cevirme D., Yuruk M. A. , Mataraci I.

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, vol.37, no.4, pp.344-347, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 4
  • Publication Date: 2014
  • Doi Number: 10.5301/ijao.5000302
  • Journal Name: INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.344-347
  • Keywords: Extracorporeal membrane oxygenation, Fondaparinux, Heparin-induced thrombocytopenia
  • Karadeniz Technical University Affiliated: Yes

Abstract

In patients with respiratory failure and impairment of the left ventricle, arteriovenous extracorporeal membrane oxygenation (ECMO) offers further therapeutic options. Systemic anticoagulation is mandatory and heparin is routinely administrated. However, repeated exposure to heparin may cause heparin-induced thrombocytopenia (HIT) and carries a risk of thrombotic mortality and morbidity. We present a patient who developed HIT during ECMO support and was treated successfully and safely by fondaparinux. Fondaparinux can be used for thromboembolic treatment or prophylaxis in a patient with HIT.