Brain atrophy and lesion burden are associated with disability progression in a multiple sclerosis real-world dataset using only T2-FLAIR: The NeuroSTREAM MSBase study

Barnett, Michael; Bergsland, Niels; Weinstock-Guttman, Bianca; Butzkueven, Helmut; Kalincik, Tomas; Desmond, Patricia; Gaillard, Frank; van Pesch, Vincent; ÖZAKBAŞ, SERKAN; Ignacio Rojas, Juan; Boz, CAVİT; Altintas, Ayse; Wang, Chenyu; Dwyer, Michael; Yang, Suzie; Jakimovski, Dejan; Kyle, Kain; Ramasamy, Deepa; Zivadinov, Robert

doi:10.1016/j.nicl.2021.102802

Brain atrophy and lesion burden are associated with disability progression in a multiple sclerosis real-world dataset using only T2-FLAIR: The NeuroSTREAM MSBase study

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Barnett M., Bergsland N., Weinstock-Guttman B., Butzkueven H., Kalincik T., Desmond P., ...More

NEUROIMAGE-CLINICAL, vol.32, 2021 (SCI-Expanded)

Publication Type: Article / Article
Volume: 32
Publication Date: 2021
Doi Number: 10.1016/j.nicl.2021.102802
Journal Name: NEUROIMAGE-CLINICAL
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals
Keywords: Multiple sclerosis, Disability progression, Brain atrophy, Lateral ventricle volume, Lesion burden, Salient central lesion volume, RESONANCE-IMAGING OUTCOMES, GRAY-MATTER ATROPHY, ROUTINE CLINICAL-PRACTICE, RETROSPECTIVE ANALYSIS, RECEIVING FINGOLIMOD, DISEASE-ACTIVITY, NO EVIDENCE, MRI, MS, RELEVANCE
Karadeniz Technical University Affiliated: Yes

Abstract

Background: Methodological challenges limit the use of brain atrophy and lesion burden measures in the followup of multiple sclerosis (MS) patients on clinical routine datasets.