Synthesis of new bis-1,2,4-triazole derivatives

Bekircan O., Bektas H.

MOLECULES, vol.11, no.6, pp.469-477, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 6
  • Publication Date: 2006
  • Doi Number: 10.3390/11060469
  • Journal Name: MOLECULES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.469-477
  • Keywords: 4-amino-4H-1,2,4-triazoles, bis-1,2,4-triazoles, bis-Schiff bases, bis-aldehydes, ANTIMICROBIAL ACTIVITY, ANTIBACTERIAL, ANTICANCER, ANTIFUNGAL
  • Karadeniz Technical University Affiliated: Yes


A series of new 1,2/1,3-bis[o-(N-methylidenamino-3-aryl-5-phenyl-4H-1,2,4-triazole-4-yl)phenoxy]ethane/propane derivatives 4 were prepared in good yields by treatment of 4-amino-3-aryl-5-phenyl-4H-1,2,4-triazoles 2 with certain bis-aldehydes 1. Compounds 4 were reduced with NaBH4 to afford the corresponding 1,2/1,3-bis[o-(Nmethylamino-3-aryl-5-phenyl-4H-1,2,4-triazole-4-yl)phenoxy]ethane/propane derivatives 5. All new compounds were characterized by IR, H-1-NMR, C-13-NMR and mass spectral data.