Elevated concentrations of serum ischaemia-modified albumin in PCOS, a novel ischaemia marker of coronary artery disease

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GÜVEN S., KARAHAN S. C., BAYRAM C., UCAR U., OZEREN M.

REPRODUCTIVE BIOMEDICINE ONLINE, cilt.19, sa.4, ss.493-500, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 4
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/j.rbmo.2009.05.012
  • Dergi Adı: REPRODUCTIVE BIOMEDICINE ONLINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.493-500
  • Anahtar Kelimeler: coronary artery disease, ischaemia-modified albumin, oxidative stress, PCOS, serum, testosterone, POLYCYSTIC-OVARY-SYNDROME, OXIDATIVE STRESS, CARDIOVASCULAR RISK, MYOCARDIAL-ISCHEMIA, PULMONARY-EMBOLISM, INSULIN-RESISTANCE, WOMEN, DIAGNOSIS, HYPERANDROGENISM, HOMOCYSTEINE
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

This prospective case-control Study comprised 41 consecutive patients with PCOS and 41 non-PCOS control patients matched for body mass index (BMI) and age (mean age, 22.17 +/- 4.45 and 23.29 +/- 3.11 years, respectively). Serum IMA, fasting glucose, fasting insulin, homeostatic model assessment insulin resistance index (HOMA-IR), prolactin, thyroid-stimulating hormone, LH, FSH, oestradiol, total testosterone, dehydroepiandrosterone sulphate, high-density lipoprotein (HDL) cholesterol, triglyceride, 17-alpha-hydroxyprogesterone and cortisol concentrations were measured. Compared with the control group, women with PCOS had significantly higher concentrations of LH (P<0.001), LH/FSH ratio (P<0.001), fasting insulin (P<0.001), HOMA (P<0.001) and total testosterone (P=0.031). Serum IMA concentrations in PCOS women were significantly higher than control group (0.63 +/- 0.26 versus 0.49 +/- 0.16 absorbance units, respectively, P=0.003, 95% CI 0.05-0.24). Bivariate analysis revealed that serum IMA concentrations were only well correlated with the Ferriman-Gallwey score (r=0.416, P=0.007), total testosterone (r=0.357, P=0.022) and BMI (r=0.3751, P=0.016) in PCOS group. Serum IMA, which has recently been developed as a clinical marker of ongoing myocardial ischaemia, appears to be elevated in PCOS. This may be due to increased androgen concentrations observed in PCOS.